Evidence map›Paper›PMID 41397865›Full record

ArticleThe Journal of rheumatology2026

Examination of HLA-DRB1*15-linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions.

Dale M Kobrin, D Garrett Brown, Peter D Burbelo, Lisa Workman, Emily D Rosenbaum, Mariana Correia Marques, Carol Lake, Michelle Millwood, Monica G Lawrence, Zuoming Deng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dale M KobrinD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland.ORCID 0009-0000-2870-5959
D Garrett BrownD.G. Brown, PhD, S. Das, MBBS, MD, D(ABMM), Department of Laboratory Medicine, NIH, Bethesda, Maryland.ORCID 0000-0001-8779-7048
Peter D BurbeloP.D. Burbelo, PhD, Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland.ORCID 0000-0003-1717-048X
Lisa WorkmanL. Workman, BA, M.G. Lawrence, MD, Division of Asthma, Allergy, and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia.
Emily D RosenbaumD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland.
Mariana Correia MarquesD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland.ORCID 0000-0002-1195-1595
Carol LakeD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland.
Michelle MillwoodD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland.
Monica G LawrenceL. Workman, BA, M.G. Lawrence, MD, Division of Asthma, Allergy, and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0001-6450-3182
Zuoming DengZ. Deng, PhD, Biodata Mining and Discovery Section, NIAMS, NIH, Bethesda, Maryland, USA.
Sanchita DasD.G. Brown, PhD, S. Das, MBBS, MD, D(ABMM), Department of Laboratory Medicine, NIH, Bethesda, Maryland.ORCID 0000-0002-2246-7942
Michael J OmbrelloD.M. Kobrin, MD, E.D. Rosenbaum, BA, M. Correia Marques, MD, C. Lake, FNP-BC, M. Millwood, BSN, M.J. Ombrello, MD, Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Michael.Ombrello@nih.gov.ORCID 0000-0003-3322-4089

Funding

Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseasesZIAAR041198 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI OMBRELLO, MICHAEL · 2014 to 2025
$14.4M
Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AR041198
6 · The paper itself

Abstract

objectiveLung disease (LD) in systemic juvenile idiopathic arthritis and adult-onset Still disease (Still-LD) is a severe manifestation strongly associated with HLA-DRB1*15 alleles and drug-associated immune reactions (DAIR), including eosinophilia, non-Still disease rashes, and elevated liver function tests. Despite the high morbidity and mortality of these phenomena, pathogenesis remains poorly understood. This study investigates whether Still-LD and DAIR are associated with pathogenic antigens through hypersensitivity reactions to

methodsPediatric and adult subjects were drawn from the National Institutes of Health Still disease cohort. Subjects with Still-LD and/or DAIR were identified by chart review. Serum samples were analyzed for anti-

resultsFifty-four subjects were included in the study, 11 had LD and DAIR, and 8 had DAIR alone. Thirty-three subjects were tested for anti-

conclusionThe absence of anti-

Indexed as

Arthritis, JuvenileHLA-DRB1 ChainsAdolescentAdultAspergillus fumigatusChildChild, PreschoolFemaleHerpesvirus 6, HumanHumansImmunoglobulin EMaleMiddle AgedYoung AdultHLA-DRB1 ChainsImmunoglobulin Eadult-onset Still diseaseallergic bronchopulmonary aspergillosisdrug hypersensitivity syndromehuman herpesvirus 6juvenile arthritispulmonary alveolar proteinosis

Identifiers

PMID41397865
PMCPMC12710775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.