ArticleThe Journal of rheumatology2026
Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative.
Article in The Journal of rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review).International journal of molecular medicine · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveDietary factors related to inflammation, obesity, and metabolism may contribute to osteoarthritis (OA) development. This study examines the relationship between metabolomic signatures of dietary patterns and radiographic knee OA incidence.
methodsThis case-cohort study included 603 participants from the Osteoarthritis Initiative, comprising 237 incident radiographic knee OA cases and 366 noncases during a 6-year follow-up. Plasma metabolomes were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry. We averaged metabolite levels at baseline and year 1 as the exposure and identified incident cases with those who had a Kellgren-Lawrence grade ≥ 2 in follow-ups. We selected 46 metabolites significantly associated with major food groups based on previous studies. Principal component analysis identified 4 metabolomic signatures related to specific food groups. Weighted logistic regression was used to examine associations between metabolomic signature scores and knee OA incidence.
resultsAmong the 603 participants, after adjusting for age, sex, and other covariates, the highest quartiles of 2 metabolomic signatures associated with healthy food groups were linked to a reduced OA risk compared to the lowest quartile (odds ratio [95% CI] 0.69 [0.44-1.08] and 0.61 [0.40-0.92], respectively). However, after further adjustment for BMI, these associations weakened. The proportions of the associations mediated through BMI for these 2 signatures were 43.7% and 81.4%, respectively. The other signatures were null.
conclusionMetabolomic signatures of healthy dietary patterns may be linked to a lower risk of radiographic knee OA, with BMI potentially playing an intermediary role. Further studies are needed to explore causality.
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