ArticleMolecular metabolism2026
Long-term high-protein diet intake accelerates adipocyte senescence through macrophage CD38-mediated NAD
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Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Who cites it
2 citing papers in PubMed.
- Adipose FGF21 signalling mediates the anti-senescence effects of protein restriction.The Journal of physiology · 2026Article
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
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Authors and funding
16 authors.
Xiaohan YangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Lun HuaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. Electronic address: hualun@sicau.edu.cn.
Dengfeng GaoState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Yanni WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yi YangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Xianyang JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Xuemei JiangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Chao JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Bin FengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Long JinState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Mingzhou LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China. Electronic address: mingzhou.li@sicau.edu.cn.
De WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. Electronic address: wude@sicau.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-protein (HP) diets are widely adopted in Western societies for body-weight management; yet, they exacerbate senescence-associated metabolic deterioration, posing an unresolved pathophysiological conundrum. Here, we demonstrate that long-term HP intake mediates adipocyte-specific NAD
Indexed as
AdipocytesADP-ribosyl Cyclase 1Cellular SenescenceDietary ProteinsMacrophagesNADAdipose Tissue, WhiteAnimalsMaleMembrane GlycoproteinsMiceMice, Inbred C57BLADP-ribosyl Cyclase 1Cd38 protein, mouseDietary ProteinsMembrane GlycoproteinsNADAdipocyte senescenceCD38High protein dietNicotinamide adenine dinucleotide
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.