ArticleInternational journal of radiation oncology, biology, physics2026
Clinical Pilot Study of Ionizing Radiation Acoustic Imaging for Real-Time Visualization of Radiation Therapy Dose Delivery in Cancer Patients.
Article in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Ionizing radiation acoustic beam localization: one step towards "proton surgery".medRxiv : the preprint server for health sciences · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
purposeThis study aimed to evaluate the feasibility of using ionizing radiation acoustic imaging (iRAI) to map the delivered dose in patients receiving radiation therapy (RT) with various treatment techniques, including 3-dimensional conformal RT, intensity modulated RT, and volumetric modulated arc therapy. METHODS AND MATERIALS: Patients with intra-abdominal cancer were enrolled in a prospective clinical trial after providing informed consent. Patients were treated with stereotactic body RT using standard clinical techniques with the addition of volumetric iRAI for real-time mapping of 3-dimensional radiation dose deposition.
resultsThe minimal detectable dose was approximately 10 cGy. The overall shape of the dose distribution and the location of dose deposition, as determined by iRAI, matched the corresponding treatment plan. A gamma passing rate of 75.97% ± 11.12% and 90.99% ± 6.61% with a 10 mm/10% distance to agreement/dose difference suggests good agreement between the iRAI measurement and the treatment plan in both the liver volume and the planning target volume under the current system resolution. A structural similarity value of 0.6284 ± 0.1678 demonstrates that the iRAI measurements have shown structural pattern agreement with the treatment plan within the planning target volume.
conclusionsThis study demonstrates the clinical feasibility of iRAI to monitor radiation dose delivery to deep targets in real time during treatment. This information can be integrated into treatment delivery systems to improve safety and facilitate the adaptation of RT. Despite the promising results achieved with the current form of technology, limitations in detection sensitivity, reconstruction accuracy, and acoustic coupling still need to be addressed.
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