Evidence map›Paper›PMID 41397399›Full record

ArticleNephrology (Carlton, Vic.)2025

Collapsing Glomerulopathy in Brazil: A Nationwide Descriptive Study.

Marcos Adriano Garcia Campos, Precil Diego Miranda de Meneses Neves, Érico Murilo Monteiro Cutrim, Andressa Monteiro Sodré, João Victor Carvalho, Davi Campos Wanderley, Stanley de Almeida Araújo, Ricardo Miranda Borges, Luiz Fernando Onuchic, Andréia Watanabe and 17 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Marcos Adriano Garcia CamposDuke Global Health Institute, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-8924-1203
Precil Diego Miranda de Meneses NevesNephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.
Érico Murilo Monteiro CutrimMedical School (HCFMB), São Paulo State University (UNESP), Botucatu, Brazil.
Andressa Monteiro SodréLaboratory Immunofluorescence and Electronic Microscopy, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.
João Victor CarvalhoLaboratory Immunofluorescence and Electronic Microscopy, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.
Davi Campos WanderleyNephropathology Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Stanley de Almeida AraújoNephropathology Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Ricardo Miranda BorgesNephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.
Luiz Fernando OnuchicNephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.
Andréia WatanabeNephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.
Irene de Lourdes NoronhaNephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.
Vanessa Dos Santos SilvaMedical School (HCFMB), São Paulo State University (UNESP), Botucatu, Brazil.
Igor Denizarde Bacelar MarquesNephrology Service, University Hospital, Federal University of Piauí (HU-UFPI), Teresina, Brazil.
Felipe Leite GuedesNephrology Service, Onofre Lopes University Hospital, Federal University of Rio Grande Do Norte (HUOL-UFRN), Natal, Brazil.
José Bruno de AlmeidaNephrology Service, Onofre Lopes University Hospital, Federal University of Rio Grande Do Norte (HUOL-UFRN), Natal, Brazil.
Rafael Fernandes Vanderlei VascoDivision of Nephrology, University Hospital, Federal University of Alagoas (UFAL), Maceio, Brazil.
Antônio MonteiroDivision of Nephrology, Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso Do Sul (HUMAP-UFMS), Campo Grande, Brazil.
Francisco Rasiah LadchumananandasivamNephrology Service, Lauro Wanderley University Hospital, Federal University of Paraíba (HULW-UFPB), João Pessoa, Brazil.
Orlando Vieira GomesDivision of Nephrology, University Hospital, Federal University of Vale Do São Francisco (HU-UNIVASF), Petrolina, Brazil.
Antonio Augusto Lima Teixeira JúniorRibeirão Preto Medical School, University of São Paulo (PGGEN-FMRP-USP), Ribeirão Preto, Brazil.
Karla Cristina Petruccelli IsraelDepartment of Clinical Medicine, Federal University of Amazonas (UFAM), Manaus, Brazil.
Denise Maria do Nascimento CostaNephrology Service, Clinical Hospital, Federal University of Pernambuco (UFPE), Recife, Brazil.ORCID https://orcid.org/0000-0001-7306-7044
Fernanda Pinheiro Martin TapiocaNephrology Service, Ana Nery Hospital, Salvador, Brazil.ORCID https://orcid.org/0000-0003-2441-9626
Epitácio Rafael da Luz NetoNephrology Service, Ana Nery Hospital, Salvador, Brazil.ORCID https://orcid.org/0009-0000-7018-1810
Joyce Santos LagesLaboratory Immunofluorescence and Electronic Microscopy, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.
Natalino Salgado FilhoLaboratory Immunofluorescence and Electronic Microscopy, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.
Gyl Eanes Barros SilvaLaboratory Immunofluorescence and Electronic Microscopy, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimCollapsing glomerulopathy (CG) is a glomerular disease that progresses rapidly to renal replacement therapy (RRT). Brazil is a conducive site for studies on CG because of its significant burden of infectious diseases and a high frequency of APOL1 risk variants. We described the clinical characteristics, histopathological findings, and outcomes of CG patients.

methodsThis retrospective survey analysed data from 2014 to 2022 from 18 centres of nephrology in all Brazilian regions. CG was diagnosed by kidney biopsy (KB), and the data were collected from medical records: initial symptoms, treatment, evolution to RRT.

resultsA total of 330 patients were included. Most patients were men (61.2%) and of Brown/Black ethnicity (72.7%). The mean age was 32 years. The most common symptoms were loss of renal function (44.2%), nephrotic proteinuria (80.07%), and hematuria (52.31%). KB revealed mild tubular atrophy and interstitial fibrosis (53.3%), moderate-to-severe interstitial inflammation (35.9%), and acute tubular necrosis (19.0%). On immunofluorescence, IgM (75.5%) and C3 (81.2%) were found to be most frequently deposited. Secondary etiologies were identified in 94 patients: HIV (13.8%), autoimmune disease (15.9%), and APOL1 high-risk genotype (48.6%, 35/72). The mean follow-up period was 13 months. Nephrotic proteinuria persisted in 78.8% of patients, and 30.5% progressed to RRT within 3 months after diagnosis.

conclusionCG affects young patients, leading to RRT in one-third of cases in approximately 3 months. This multicentre study sets the baselines for risk factors and outcomes in the largest population studies on CG.

Indexed as

Glomerulosclerosis, Focal SegmentalAdolescentAdultApolipoprotein L1BiopsyBrazilDisease ProgressionFemaleHumansKidney GlomerulusMaleMiddle AgedRenal Replacement TherapyRetrospective StudiesRisk FactorsYoung AdultAPOL1 protein, humanApolipoprotein L1chronic kidney diseasecollapsing glomerulopathyepidemiologykidney biopsyrenal replacement therapy

Identifiers

PMID41397399
PMCPMC12705224

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