Evidence map›Paper›PMID 41397376›Full record

ArticleBiofabrication2025

An

Angelo Massaro, Cecilia Villegas Novoa, Nancy L Allbritton

Abstract read
In one paragraph

Article in Biofabrication, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. AnBiofabrication · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Angelo MassaroDepartment of Bioengineering, University of Washington, Seattle, WA, United States of America.ORCID 0000-0002-0529-4410
Cecilia Villegas NovoaDepartment of Bioengineering, University of Washington, Seattle, WA, United States of America.ORCID 0000-0003-0522-6829
Nancy L AllbrittonDepartment of Bioengineering, University of Washington, Seattle, WA, United States of America.ORCID 0000-0002-9242-768X

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancerR01CA289291 · NCI · UNIVERSITY OF WASHINGTON · PI Nancy L. Allbritton, Cole A DeForest · 2024 to 2026
$1.6M
A Human Gut-Liver Platform with Microbiome Interactions for In Vitro ToxicologyR21ES036001 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALLBRITTON, NANCY L., KHETANI, SALMAN R · 2024 to 2025
$449k
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA289291NIEHS NIH HHS R21 ES036001
6 · The paper itself

Abstract

Stiffening of the extracellular matrix underlying the epithelial cells of the large intestine is associated with aging as well as many diseases. Yet the impact of the stiffened matrix on epithelial physiology remains poorly understood. A 2D and 3D microphysiological model of the large intestine was developed using a collagen scaffold with a physiologic or excessive stiffness (Young's moduli of 2.84 ± 0.85 kPa and 15.9 ± 0.73 kPa) by altering the collagen concentration within the substrate. Diffusion of a 10 and 40 kDa fluorescent dextran was significantly different between the physiologic and stiff scaffold (97.8 vs 79.8

Indexed as

ColonEpithelial CellsIntestinal MucosaCell ProliferationCells, CulturedCollagenExtracellular MatrixHumansTissue EngineeringTissue ScaffoldsCollagencolon cryptsintestinemicrophysiologic systemsorgan-on-chipstiff matrix

Identifiers

PMID41397376
PMCPMC12745674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.