Evidence map›Paper›PMID 41397263›Full record

ArticleThe journal of physical chemistry letters2025

Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core.

Haidara Nadwa, Z Faidon Brotzakis, Annalisa Santucci, Daniela Braconi, Michele Vendruscolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haidara NadwaDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0009-0005-1392-9454
Z Faidon BrotzakisInstitute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", 34 Fleming Street, 16672 Vari, Greece.ORCID 0000-0001-7024-1430
Annalisa SantucciDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0001-6976-9086
Daniela BraconiDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-9657-4169
Michele VendruscoloCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Rd., CB21EW Cambridge, U.K.ORCID 0000-0002-3616-1610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum amyloid A (SAA) is the principal precursor of AA amyloidosis, yet the early molecular steps that trigger its pathological misfolding remain unclear. Here, we combine harmonic linear discriminant analysis (HLDA) and parallel-tempering metadynamics (PT-MetaD) to dissect the earliest conformational transitions of the disease-relevant SAA

Indexed as

Serum Amyloid A ProteinAmyloidHumansMolecular Dynamics SimulationProtein FoldingProtein Structure, SecondaryThermodynamicsAmyloidSerum Amyloid A Protein

Identifiers

PMID41397263
PMCPMC12746452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.