ArticlePLoS neglected tropical diseases2025
Intestinal immunopathological evaluation of mice reinfected with Trypanosoma cruzi Y strain.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is influenced by both host-related factors and parasite characteristics, including reinfection and strain variability. While the heart is the primary focus of reinfection studies, the effects on the intestinal form of the disease remain poorly understood. METHODOLOGY/PRINCIPAL
findingsIn this study, C57BL/6 male mice were infected and subsequently reinfected with the T. cruzi Y strain to assess the immunopathological consequences in the intestinal tract. We analyzed parasitemia levels, systemic cytokines, anti-T. cruzi immunoglobulin levels (IgG, IgG2a, IgG2b), inflammatory infiltrates, neuronal counts, and collagen deposition. Our data showed that reinfection led to reduced parasitemia and did not alter antibody levels generated during primary infection. However, reinfection induced a systemic reduction in IL-4 and IL-10 and an increase in IFN-γ, indicating a shift toward a pro-inflammatory profile. Histopathologically, reinfected mice exhibited intensified intestinal inflammation and increased neuronal destruction in the myenteric plexus, without additional collagen deposition compared to singly infected animals. CONCLUSIONS/SIGNIFICANCE: Although homologous reinfection may enhance parasitemia control through sustained immunoglobulin responses, it exacerbates tissue inflammation and neuronal damage. These findings underscore the dual role of immune responses in controlling parasite burden while potentially contributing to intestinal pathology, highlighting the need for caution when considering reinfection risks in endemic areas.
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