ArticleOptics letters2025
Evaluating tartrazine as an optical clearing agent for fluorescence lifetime imaging.
Article in Optics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Tartrazine Clears Live Cells while Preserving Viability at High Refractive Indices and Osmolality.Bioconjugate chemistry · 2026Article
- In vivo tissue clearing with tartrazine and other dye molecules.Communications biology · 2026Review
- Tartrazine clears live cells while preserving viability at high refractive indices and osmolality.bioRxiv : the preprint server for biology · 2026Article
- Real-time wide-field fluorescence lifetime imaging via single-snapshot acquisition for biomedical applications.PhotoniX · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fluorescence lifetime imaging (FLI) offers valuable insights into the molecular and functional properties of biological tissues. However, in deeper tissues, optical properties (scattering and absorption) diminish fluorescence signal significantly and complicate data interpretation. This study explores the potential of tartrazine (FD&C Yellow 5), a biocompatible and FDA-approved food dye, as an optical clearing agent for deep tissue imaging. Despite its own near-infrared (NIR) fluorescence, tartrazine's ultrashort intrinsic lifetime (∼0.10 ns) allows for effective separation from the longer lifetimes of conventional NIR probes (>0.50 ns) using lifetime-based unmixing. We found that at an optimal concentration (≤ 0.6 M), tartrazine brings down the reduced scattering coefficient (
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Registered trials
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