ArticleAge and ageing2025
A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials.
Article in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Barriers and facilitators to recruiting older adult care home residents into clinical trials of medicines and vaccines: a scoping review.Age and ageing · 2026Article
- Participatory development of innovation and implementation strategy - an action-oriented approach.BMC health services research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
introductionOlder care home (CH) residents are particularly vulnerable to infections and often experience adverse outcomes. Despite this group being frequently prioritised for vaccinations, trials of vaccines rarely recruit CH residents. Given that the social and biological characteristics of CH residents may influence vaccine effectiveness, it is crucial to test vaccines in this population.
methodsThe Widening Access to Trials in Care Homes project was established to develop best practice guidance on designing and conducting vaccine trials in the CH population. As part of this project, a scoping review following Joanna Briggs Institute methodology was conducted to identify vaccine trials involving CH residents. Search conducted in EMBASE, MEDLINE, PsycINFO, CINAHL and Cochrane Library, from 1990 to 2025. Results presented as descriptive summaries.
resultsWe retrieved 701 articles and included 20 studies. A total of 7479 participants from 238 CHs were recruited to influenza or pneumococcal vaccine trials. The weighted mean age was 82.3 years. Screen failure averaged 70% (eight studies), primarily due to declining participation (46%) and not meeting eligibility criteria (27%). Dropout averaged 8% (11 studies), with death (21%) being the most common reason. Identified barriers include eligibility criteria and recruitment, consent and assent issues, ethical and regulatory, CH-related factors and study time frame and logistical factors. Facilitators include recruitment and data collection methods, consent and assent factors and collaboration with CHs.
conclusionOur review is the first to synthesise both quantitative and qualitative evidence on recruiting CH residents into vaccine trials and to provide suggestions for future trial design in this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.