Evidence map›Paper›PMID 41396779›Full record

ArticleChemistry & biodiversity2026

Anti-Inflammatory and Lipid Metabolism Modulatory Effects of Lantana camara L. Extract, With Enhanced Fibroblast Migration.

Ari S de O Lemos, Matheus T Branca, Lara M Campos, Natasha S Mayrink, Lívia R Gamarano, João Pedro R C Bastos, Ana Julia de Almeida, Elaine S Coimbra, Rodrigo L Fabri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ari S de O LemosBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Matheus T BrancaBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Lara M CamposBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Natasha S MayrinkBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Lívia R GamaranoBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
João Pedro R C BastosDepartment of Parasitology, Microbiology, and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Ana Julia de AlmeidaBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Elaine S CoimbraDepartment of Parasitology, Microbiology, and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Rodrigo L FabriBioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.ORCID https://orcid.org/0000-0002-0167-2277

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408700/2021-1Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01357-21Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01646-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00198-23
6 · The paper itself

Abstract

Inflammation is a complex process associated with various chronic diseases. Lantana camara L., widely used in traditional medicine, exhibits diverse bioactivities, though its effects on lipid metabolism, prostaglandin E2 (PGE2) production in macrophages, and fibroblast migration remain unclear. This study aimed to evaluate whether the ethanolic extract from L. camara leaves (LCE) influences these processes. Phytochemical analysis by an ultra-fast liquid chromatography-quadrupole time of flight mass spectrometry identified flavonoids and iridoid glycosides in the extract. Cytotoxicity assays using BALB/c mouse peritoneal macrophages and L929 fibroblasts showed no significant effect on cell viability. Anti-inflammatory activity was assessed through nitric oxide (NO), reactive oxygen species (ROS), lipid bodies (LB), and levels of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, and PGE2. LCE significantly reduced NO (74.61 ± 5.08%), ROS (58.38 ± 1.77%), and LB formation (53.56 ± 3.33%), as well as TNF-α (40.63 ± 1.33%), TGF-β (88.96 ± 12.87%), and PGE2 (56.88 ± 27.10%) levels. Wound healing potential was evaluated via scratch assay, with LCE promoting fibroblast migration up to 86.26 ± 0.81% after 48 h. These findings indicate that LCE modulates macrophage inflammatory responses and promotes tissue repair, supporting its potential as a natural therapeutic agent for managing inflammation, oxidative stress, and wound healing.

Indexed as

Anti-Inflammatory AgentsFibroblastsLantanaLipid MetabolismPlant ExtractsAnimalsCell LineCell MovementCell SurvivalDinoprostoneDose-Response Relationship, DrugMiceMice, Inbred BALB CNitric OxidePlant LeavesReactive Oxygen SpeciesAnti-Inflammatory AgentsDinoprostoneNitric OxidePlant ExtractsReactive Oxygen SpeciesCambarácomplex inflammatory processcytokinesnitric oxidewound healing

Identifiers

PMID41396779
PMCPMC12860513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.