Evidence map›Paper›PMID 41396559›Full record

ArticleMolecular biology reports2025

NLRP1 gene polymorphism rs2670660 is associated with vitiligo in the Pakistani population.

Sehresh Murtaza, Nasir Masood, Maleeha Azam, Muhammad Ajmal

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Sehresh MurtazaTranslational Genomics Laboratory, Department of Biosciences, Faculty of Health Sciences, COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad, 45550, Pakistan.
Nasir MasoodTranslational Genomics Laboratory, Department of Biosciences, Faculty of Health Sciences, COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad, 45550, Pakistan.
Maleeha AzamTranslational Genomics Laboratory, Department of Biosciences, Faculty of Health Sciences, COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad, 45550, Pakistan.
Muhammad AjmalTranslational Genomics Laboratory, Department of Biosciences, Faculty of Health Sciences, COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad, 45550, Pakistan. chmajmal@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most prevalent type of acquired depigmentation disorder is vitiligo, which is characterized by the development of white spots on the skin, hair, and mucous membranes due to melanocyte loss. It is a polygenic and multifactorial disease with complicated genetic and environmental pathogenesis. The onset and progression of vitiligo are strongly influenced by both genetic and environmental variables, including neurological effects, oxidative-antioxidative stress, and immune dysfunction. METHODS AND

resultsThe polymorphism (rs2670660) in the NLRP1 gene was analyzed in 110 patients with vitiligo and 110 healthy controls matched for age and sex. Tetra-ARMS PCR was used to determine the genotypes, and Sanger sequencing was employed to validate the three genotypes. Initial genotype analysis revealed significant differences in genotype distribution between cases and control (p = 0.035). Further analysis of the genotype data showed that the frequency of the GG genotypes was significantly higher in vitiligo cases than in controls under the recessive model (odds ratio [OR] 2.647; 95% confidence interval [CI] 1.230-5.695; p-value = 0.011). Moreover, the prevalence of the G allele was also significantly higher in the patient group (P = 0.019, OR = 1.595, 95% CI = 1.081-2.353).

conclusionIn conclusion, the NLRP1 polymorphism rs2670660 is significantly associated with the onset of vitiligo in the Pakistani population.

Indexed as

Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsNLR ProteinsVitiligoAdolescentAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsNLRP1 protein, humanNLR ProteinsAutoimmuneCase-control studyGeneticsNLRP1 genePopulationVitiligo

Identifiers

PMID41396559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.