Evidence map›Paper›PMID 41396550›Full record

ArticleACS applied bio materials2026

Graphene Oxide Composites with Ultrahigh-Molecular-Weight Polyethylene for Innovative Prostheses for Arthroplasty.

Ahmed Subrati, Thyago Arruda Pacheco, Ítalo Azevedo Costa, Victor Carlos Mello, John Fredy Ricardo Marroquin, Mikołaj Kościński, Ludmila Alvim Gomes Pinho, Ariane Pandolfo Silveira, Jorlandio F Felix, Marcilio Cunha-Filho and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Navigating theNanoscale advances · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ahmed SubratiCentro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE), Donostia-San Sebastián, Guipúzcoa 20009, Spain.ORCID 0000-0001-6770-0501
Thyago Arruda PachecoInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Ítalo Azevedo CostaPolymer and Nanomaterials Research Laboratory, Chemistry Institute, University of Brasilia, Brasilia, Distrito Federal 70910-900, Brazil.
Victor Carlos MelloInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
John Fredy Ricardo MarroquinLabINS BSS 297, Institute of Physics, University of Brasília, Brasília 70910-900, Brazil.ORCID 0000-0002-1969-452X
Mikołaj KościńskiFaculty of Physics and Astronomy, Adam Mickiewicz University, Uniwersytetu Poznańskiego 2, Poznań 61-614, Poland.
Ludmila Alvim Gomes PinhoLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Brasília, Distrito Federal 70910-900, Brazil.
Ariane Pandolfo SilveiraInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Jorlandio F FelixLabINS BSS 297, Institute of Physics, University of Brasília, Brasília 70910-900, Brazil.
Marcilio Cunha-FilhoLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Brasília, Distrito Federal 70910-900, Brazil.
Marcio José Poças-FonsecaInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Ricardo Bentes de AzevedoInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Sonia Nair BáoInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-9873-3098
Rander Pereira AvelarCPMH Digital, Brasília, Distrito Federal 71200-260, Brazil.
Leonardo Giordano PaternoPolymer and Nanomaterials Research Laboratory, Chemistry Institute, University of Brasilia, Brasilia, Distrito Federal 70910-900, Brazil.ORCID 0000-0001-7716-0318
Sergio MoyaCentro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE), Donostia-San Sebastián, Guipúzcoa 20009, Spain.ORCID 0000-0002-7174-1960
João Paulo Figueiró LongoInstitute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-5154-7263

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although ultrahigh-molecular-weight polyethylene (UHMWPE) is commonly used for prosthetic devices in arthroplasty, it is also prone to abrasion and wear. This wear can ultimately result in the release of particles that may trigger aseptic necrosis and activate the immune system. Graphene oxide (GO) incorporated into UHMWPE has been proven to be an effective strategy for improving the mechanical and biological properties of this commercial material. We aimed to incorporate graphene oxide into UHMWPE using an innovative method without toxic solvents and characterize this UHMWPE-GO prosthetic material in terms of its physicochemical and antimicrobial properties. The results showed that the UHMWPE-GO prosthesis, compared to traditional UHMWPE prostheses, exhibited improved mechanical properties, thermal stability, biocompatibility, and increased adhesion in human fibroblasts in culture conditions. Therefore, our work has produced a material for arthroplasty prostheses that offers improved performance and good biocompatibility.

Indexed as

Anti-Bacterial AgentsArthroplastyBiocompatible MaterialsGraphitePolyethylenesCell AdhesionEscherichia coliFibroblastsHumansMaterials TestingMicrobial Sensitivity TestsParticle SizeSurface PropertiesAnti-Bacterial AgentsBiocompatible Materialsgraphene oxideGraphitePolyethylenesultra-high molecular weight polyethylenearthroplastybiocompatibilitydental prothesisgraphene oxidenanocompositeUHMWPE

Identifiers

PMID41396550
PMCPMC12776581

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.