Evidence map›Paper›PMID 41396460›Full record

ArticleJournal of neuro-oncology2025

Socioeconomic disparities in patient-reported outcomes, health literacy, and access to care among patients with primary brain tumors: findings from the All of Us Research Program.

Shailen G Sampath, Alex Hernandez Manriquez, Hannah Haile, Miles Botkiss, Chiemela Izima, Arjun R Adapa, Nathan A Shlobin, Michael G Argenziano, Cheng-Shiun Leu, Brian J A Gill

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shailen G SampathVagelos College of Physicians and Surgeons, Columbia University, New York, USA. sgs2187@cumc.columbia.edu.
Alex Hernandez ManriquezVagelos College of Physicians and Surgeons, Columbia University, New York, USA.
Hannah HaileVagelos College of Physicians and Surgeons, Columbia University, New York, USA.
Miles BotkissDepartment of Neurological Surgery, Vagelos College of Physicians and Surgeons, New York, USA.
Chiemela IzimaVagelos College of Physicians and Surgeons, Columbia University, New York, USA.
Arjun R AdapaDepartment of Neurological Surgery, Vagelos College of Physicians and Surgeons, New York, USA.
Nathan A ShlobinDepartment of Neurological Surgery, Vagelos College of Physicians and Surgeons, New York, USA.
Michael G ArgenzianoDepartment of Neurological Surgery, Vagelos College of Physicians and Surgeons, New York, USA.
Cheng-Shiun LeuMailman School of Public Health, Columbia University Irving Medical Center, New York, USA.
Brian J A GillDepartment of Neurological Surgery, Vagelos College of Physicians and Surgeons, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo understand the impact of socioeconomic disparity on patient-reported outcomes, health literacy, and access to care in primary malignant brain tumors (PMBT).

methodsWe performed a retrospective analysis of adults with PMBT using the NIH All of Us Program database. An aggregate of income, insurance, education, employment, and housing called Individual Socioeconomic Deprivation Index (iSDI) was measured for each patient and a multivariate regression was conducted to measure its effect on self-reported symptom burden, health status, health literacy, and barriers to healthcare access.

results873 patients with primary malignant brain tumors completed post-diagnosis surveys. Across these patients, higher iSDI (more deprivation) was associated with consistently worse patient-reported outcomes. Higher iSDI was strongly associated with worse fatigue, more pain, and greater emotional distress including anxiety and depression and lower functional independence (adjusted p < 0.001). Higher iSDI was also significantly linked to poorer general, mental, and physical health, as well as lower overall quality of life (all adjusted p < 0.001). Greater deprivation also increased the odds of worse patient understanding of presented written material, increased feeling of needing assistance with filling out health material, and lower confidence in filling out medical forms (all adjusted p < 0.001). In contrast, iSDI was not associated with cost-related barriers to care, including delaying prescription fills, skipping medication to save money, heightened worry about paying for medical care, or with difficulty affording follow-up care, a healthcare provider, or a specialist (all adjusted p ≥ 0.05).

conclusionsPatients socioeconomic background has a significant influence on patient-reported outcomes and health literacy in individuals with PMBT. These findings extend prior evidence linking socioeconomic background to treatment access and survival, underscoring the need for targeted interventions that address financial toxicity, and supportive care in addition to equitable access to medical information.

Indexed as

Brain NeoplasmsHealthcare DisparitiesHealth LiteracyHealth Services AccessibilityPatient Reported Outcome MeasuresAdultAgedFemaleFollow-Up StudiesHumansLow Socioeconomic StatusMaleMiddle AgedQuality of LifeRetrospective StudiesSocioeconomic Disparities in HealthAll of Us Research ProgramHealthcare disparitiesHealth literacyiSDIPatient-reported outcomesPrimary brain tumorSocioeconomic status

Identifiers

PMID41396460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.