Evidence map›Paper›PMID 41396455›Full record

ArticleJournal of vision2025

Sex differences in fixational eye movements following concussion.

Richard Johnston, Cameran Thompson, Anthony P Kontos, Min Zhang, Cyndi L Holland, Aaron J Zynda, Christy K Sheehy, Ethan A Rossi

Abstract read
In one paragraph

Article in Journal of vision, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard JohnstonDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cameran ThompsonDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Anthony P KontosDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Min ZhangDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cyndi L HollandDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Aaron J ZyndaDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Christy K SheehyC. Light Technologies, Inc., Boston, MA, USA.
Ethan A RossiDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
NCATS NIH HHS KL2 TR001856NCATS NIH HHS TL1 TR001858NCATS NIH HHS UL1 TR001857NEI NIH HHS P30 EY008098
6 · The paper itself

Abstract

Recent research supports impairments in fixational eye movements (FEMs), small motions of the eye that occur during periods when gaze is maintained on a fixed target, as an objective biomarker of concussion. Preliminary work has demonstrated that fixational saccades are larger following a concussion; however, sex differences in FEMs and fixational saccades have not been examined. In this study, we used retinal image-based eye tracking, with a tracking scanning laser ophthalmoscope (TSLO), to record FEMs while adolescents with concussion (n = 44; age range, 13-27 years) and age- and sex-matched healthy controls (n = 44; age range, 13-27 years) fixated the center or corner of the TSLO imaging raster. To improve reliability and overcome errors associated with the manual labeling of FEMs, an objective velocity-based algorithm was used to detect fixational saccades. Concussion patients made larger fixational saccades than controls but only on the center task. Females made larger fixational saccades than males on this task irrespective of injury group, whereas no significant difference was supported for the corner task. Females also made fewer horizontal and more oblique fixational saccades than males on the corner task. These findings highlight the importance of controlling for task- and sex-specific differences when evaluating FEMs as a biomarker for concussion.

Indexed as

Brain ConcussionFixation, OcularSaccadesSex CharacteristicsAdolescentAdultEye MovementsEye-Tracking TechnologyFemaleHumansMaleSex FactorsYoung Adult

Identifiers

PMID41396455
PMCPMC12710789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.