ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Objective assessment of graft clarity and recurrence after penetrating keratoplasty for granular, lattice and macular corneal dystrophy using scheimpflug densitometry.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- genotype-phenotype correlation in lattice corneal dystrophy: added diagnostic value of high-resolution OCT.Scientific reports · 2026Article
- Precision of Pachymetry Measured With a Portable High-Resolution Ultrasound, a Standard Ultrasound, and Two Scheimpflug Pachymeters.Journal of ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate long-term outcomes and recurrence patterns following penetrating keratoplasty (PKP) in granular (GCD), lattice (LCD), and macular corneal dystrophy (MCD), using Scheimpflug-based corneal densitometry (grayscale units-GSU) as an objective tool to assess graft clarity.
methodsIn this retrospective single-center study, 99 eyes of 59 patients with GCD (n = 38), LCD (n = 30), or MCD (n = 31) were analyzed. A total of 112 PKPs, including 74 excimer laser-assisted PKPs, were evaluated. Clinical examinations included visual acuity, slit-lamp evaluation, and corneal tomography using the Pentacam HR. Clinical recurrence was defined as the appearance of dystrophy-specific changes within the graft. Corneal densitometry was assessed in the anterior, central, and posterior layers and the total corneal thickness at 0-2 mm and 2-6 mm zones. Follow-up ranged from 6 weeks to more than 5 years (5y+) postoperatively.
resultsA significant postoperative improvement in BCVA was observed in eyes with GCD and MCD, with sustained visual gains up to 4y and 5y postoperatively, respectively. GCD demonstrated the earliest and highest clinical recurrence rate, with all grafts affected by 5y. LCD showed delayed recurrence from 4y onward, while MCD did not show any recurrence within 5y. Corneal densitometry revealed a progressive increase in GSU in GCD and LCD, particularly in the anterior (GCD:5y / LCD:5y+) and central layers (GCD:4y / LCD:5y+). MCD showed stable GSU values throughout follow-up. Linear regression analysis showed the strongest GSU increase in LCD (slope = 1.65, R²=0.47) and GCD (slope = 0.94, R²=0.14), particularly in the anterior 0-2 mm zone. MCD showed minimal change across all layers and diameters.
conclusionScheimpflug-based corneal densitometry enables objective, layer-specific monitoring of graft clarity and recurrence after PKP. Recurrence rates differ significantly among dystrophy subtypes, highlighting the clinical utility of densitometry in tailoring follow-up strategies, particularly in GCD and LCD with high risk of recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.