ArticleNeuroradiology2026
Net water uptake as a predictor of the development of high-density lesions after endovascular treatment.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeIodine extravasation signifies blood–brain barrier disruption and predicts hemorrhagic transformation (HT) after thrombectomy for acute ischemic stroke (AIS). We aimed to evaluate the role of net water uptake (NWU) in patients with acute anterior circulation ischemic stroke who developed high-density lesions on computed tomography (CT) after endovascular treatment (EVT).
methodsThis retrospective study included patients who underwent dual-energy CT immediately after EVT for acute anterior circulation occlusion between January 2022 and December 2023. Alberta Stroke Program Early CT Score (ASPECTS)-based NWU was calculated using baseline non-contrast CT. The clinical endpoint was presence of high-density lesions after EVT. A final clinical imaging model incorporating NWU was constructed.
resultsIn total, 109 patients (mean age, 68.2 ± 12.8 years; 42 male participants) were evaluated, with 67 (61.5%) patients showing high-density lesions after EVT. Multivariable logistic regression analysis identified the National Institutes of Health Stroke Scale (NIHSS) score (odds ratio = 1.049; 95% confidence interval [CI]: 1.004–1.096; p = 0.033) and NWU (odds ratio = 1.396; 95% CI: 1.170–1.666; p < 0.001) as predictors of high-density appearance post-EVT. The receiver operating characteristic curve showed an area under the curve of 0.663 (95% CI: 0.557–0.768) for the NIHSS-based model and 0.778 (95% CI: 0.690–0.867) when NWU was included.
conclusionASPECTS-based quantitative NWU independently predicted high-density lesions post-EVT, implying that it can assist in early patient risk stratification. Baseline NWU, indicating brain tissue edema, could forecast blood–brain barrier disruption following EVT.
Indexed as
Identifiers
41396428What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.