ArticleCell biochemistry and biophysics2026
Analytical and Molecular Insights into the Cu(II)-Schiff Base System: Electrochemical Redox Behavior, Thermodynamic Evaluation, and DNA Affinity.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Electrochemical Investigation of Cu(II) Complexation with a Novel Pyridine-Based Schiff Base Ligand: Cyclic Voltammetry, Molecular Docking, and Antioxidant Evaluation.Cell biochemistry and biophysics · 2026Article
- Synthesis, spectroscopic, characterization, antimicrobial, DNA interaction, DFT and molecular docking studies of a new Cu(II)-Schiff base complex.Scientific reports · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
A Cu(II)–Schiff base complex was examined through electrochemical, spectroscopic, and biological methods. Cyclic voltammetry in KCl solution showed concentration- and scan rate-dependent redox behavior, from which diffusion coefficients, stability constants, and Gibbs free energies were derived. Reduced current intensity and potential shifts upon ligand addition confirmed stable, spontaneous Cu–ligand complexation. The DPPH assay revealed strong antioxidant activity (IC₅₀ = 0.0704 mg/mL), comparable to standard antioxidants. Molecular docking with the MIA protein (PDB: 5IXB) showed favorable H-bonding and π–cation interactions, indicating biomedical potential. UV–vis titration with calf thymus DNA produced hypochromic and a slight redshift, suggesting intercalative binding with Kb ≈ 10⁴–10⁵ M⁻¹. Overall, the Cu–Schiff base complex exhibits redox activity, antioxidant capacity, and DNA affinity suitable for biosensing or therapeutic applications.
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Registered trials
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