ReviewMolecular biology reports2025
Targeting autophagy and metabolism for ewing sarcoma.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ewing sarcoma is a common, aggressive and highly metastasizing bone and soft tissues tumor that most frequently affects children, adolescents and young adults and leads to death. Despite advances over the last four decades that have improved the 5-year survival rate, the recurrence rate remains high. Autophagy plays a role in quality control by eliminating toxic cellular components under normal conditions, maintaining cell viability and establishing cellular adaptability under stressful conditions. The studies highlight autophagy as a tumor promoter or tumor suppressor and hence caution should be maintained when considering it as a therapeutic target. The dual role of autophagy as a cytoprotective and cytotoxic mechanism underscores its significance in cancer. One of the hallmarks of cancer is dysregulated metabolism in which the biosynthetic demands of highly proliferating malignant cells necessitate the rewiring of metabolic pathways. Research has shown the significance of amino acids, glucose and lipid metabolism in the development of cancer. Despite much research on Ewing sarcoma, there are still many unanswered questions and difficulties regarding the functions and outcomes of autophagy and metabolism in the treatment. This minireview aims to investigate additional information and strategies for targeting autophagy and metabolism together in the treatment of Ewing sarcoma.
Indexed as
Identifiers
41396331What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.