ArticleInternational ophthalmology2025
Use of very young donor grafts in descemet membrane endothelial keratoplasty: perioperative and early postoperative observations.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the impact of young donor age on perioperative and early postoperative outcomes in DMEK.
methodsIn this retrospective study, 40 patients underwent DMEK using donor tissue sourced from either individuals younger than 40 years (Group 1, n = 20; age range: 19-39 years) or individuals older than 40 years (Group 2, n = 20; age range: 41-76 years). Data collected included recipient age, gender, diagnosis, preoperative visual acuity, donor age, ECD, graft diameter, intraoperative graft preparation time, unscrolling time, surgical complications, and graft survival at 3 months. These parameters were compared between the two groups.
resultsThere were no statistically significant differences between the groups in recipient demographics, preoperative visual acuity, donor characteristics (age, ECD, diameter), graft preparation time, unscrolling time, or corneal clarity at 3 months (p > 0.05). Minor tears occurred in two cases in Group 1 and one case in Group 2, but these grafts were still usable. Only one patient in Group 2 required a replacement graft due to a large tear. Resistant peripheral graft folds were observed in nine cases in Group 1 and one in Group 2, but none required postoperative rebubbling or led to surgical failure.
conclusionThe use of young donor tissue in DMEK does not appear to negatively impact surgical outcomes. Further studies with longer follow-up are needed to assess long-term graft survival and validate the broader use of young donors in DMEK.
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