The ameliorative effects of fermented Chinese herbal medicine on growth inhibition and liver damage induced by manganese exposure in largemouth bass (Micropterus salmoides).

Pan Zhou, Qiuhong Wu, Guang Fan, Zhiwen Yang, Songsong Bao, Jin Li, Xiaofei Yang, Xinyue Liu, Fangzhou Jing, Li Jiang

Abstract read

In one paragraph

Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pan Zhou *College of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Qiuhong Wu *College of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Guang FanCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Zhiwen YangCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Songsong BaoCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Jin LiCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Xiaofei YangCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Xinyue LiuCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Fangzhou JingCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China.

Li JiangCollege of Life Sciences and Agri-Forestry, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, PR China. 1305462380@qq.com.

Funding

Southwest University of Science and Technology Graduate Innovation Fund 24ycx1158Southwest University of Science and Technology Graduate Innovation Fund 24ycx1160

6 · The paper itself

Abstract

This study aims to investigate the ameliorative effects of fermented Chinese herbal medicine (FCHM) on manganese (Mn)-induced growth inhibition and liver damage in largemouth bass. The experiment was set up with eight groups: Mn (0, 0.750, 1.125, and 1.688 mg/L) and Mn + FCHM (0, 0.750, 1.125, and 1.688 mg/L). Among these, the Mn (0 mg/L) group served as the control group. The Mn groups were fed a basal diet, while the Mn + FCHM groups were fed a diet containing 1% FCHM. The experiment lasted for 60 days. The results indicated that Mn exposure reduced growth performance and induced Mn accumulation in the liver, tissue structural damage, oxidative stress, and inflammation. One percent FCHM partially restored growth performance, increased the activity and gene expression of GSH-PX, CAT, and SOD enzymes in the liver, reduced MDA and Mn content, increased the expression of anti-inflammatory markers IL-10 and TGF-β1 mRNA, decreased the expression of IL-15, IL-8, IL-1β, and TNF-α mRNA, and alleviated liver tissue pathological damage. In summary, this study found that FCHM can improve the antioxidant capacity of largemouth bass, alleviate Mn-induced liver inflammatory damage, and thereby enhance the growth performance of largemouth bass.

Indexed as

BassChemical and Drug Induced Liver InjuryDrugs, Chinese HerbalFish DiseasesManganeseAnimal FeedAnimalsDietDietary SupplementsFermentationLiverOxidative StressDrugs, Chinese HerbalManganeseFermented Chinese herbal medicineGrowth performanceInflammatory responseLargemouth bassManganese exposureOxidative stress

Identifiers

PMID41396323

DOI10.1007/s10695-025-01619-3

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.