ArticleInternational ophthalmology2025
Comparison of the diagnostic performance of two spectral-domain OCT machines in detecting glaucoma in high and non-high axial myopia eyes.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purposeTo compare the diagnostic performance of two spectral-domain optical coherence tomography (SD-OCT) systems, Spectralis and Cirrus, in detecting glaucoma among eyes with and without high axial myopia, using peripapillary retinal nerve fiber layer (pRNFL), macular full-thickness, and ganglion cell-inner plexiform layer (GCIPL) measurements.
methodsThis prospective cross-sectional study included 333 eyes from 333 adults at a tertiary referral center. Participants were classified into four groups according to axial length (high myopia was defined as axial length ≥ 26.0 mm) and glaucoma status: non-highly myopic normal (n = 130), non-highly myopic glaucomatous (n = 101), highly myopic normal (n = 20), and highly myopic glaucomatous (n = 82). Thickness parameters, including pRNFL, macular full-thickness, and GCIPL, from both SD-OCT systems were analyzed, and diagnostic performance was assessed using receiver operating characteristic curves and area under the curve (AUC) comparisons.
resultsBoth devices detected significant thinning across pRNFL, macular full-thickness, and GCIPL measurements in glaucomatous eyes. In non-highly myopic eyes, diagnostic performance was generally comparable, although Spectralis demonstrated superior performance in the nasal pRNFL quadrant (P < 0.01). In highly myopic eyes, Spectralis outperformed Cirrus in several macular full-thickness subfields (e.g., inner and outer temporal, inner inferior, and inner superior), whereas Cirrus exhibited better performance in superior pRNFL. GCIPL parameters performed equally well in both devices, with AUC values exceeding 0.89 in highly myopic eyes.
conclusionBoth SD-OCT systems demonstrated reliable diagnostic abilities in eyes with and without high axial myopia. Spectralis showed advantages in specific macular full-thickness parameters in high axial myopia, and GCIPL metrics remained consistent and robust across both devices.
Indexed as
Identifiers
41396317What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.