Evidence map›Paper›PMID 41396212›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Biopsy and laser ablation as a treatment strategy for pediatric brain incidentalomas.

Hunter S Futch, Arman Jahangiri, Youssef M Zohdy, Jennifer Wheelus, Andrew Reisner, Jacob R Lepard, Joshua J Chern

Abstract readReview
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In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Single-center longitudinal experience with MRgLITT in pediatric neurosurgery: technical evolution, expanding indications, and advanced MRI-driven planning.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hunter S FutchDepartment of Neurosurgery, Emory University, Atlanta, GA, USA. hfutch@emory.edu.
Arman JahangiriDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Youssef M ZohdyDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Jennifer WheelusDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Andrew ReisnerDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Jacob R LepardDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Joshua J ChernDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate a combined biopsy-ablation procedure as an early intervention in small brain incidentalomas.

methodsPatient selection criteria included lesion in deep location, lesion growing over time, and lesion over 1 cm but less than 1.5 cm in diameter. Four patients underwent robotic-assisted stereotaxic biopsy followed by laser interstitial thermal therapy (LITT). Patients were then followed with MRI over time.

resultsAt time of operation, patients' age was between 10 and 16 years. Biopsy revealed pilocytic astrocytoma (n = 2) and dysembryonic neuroepithelial tumor (DNET), and one specimen was indeterminate for pathological changes. Imaging follow-up was between 17 and 72 months. None of the lesions showed progression on repeat MRI.

conclusionsBased on published data, it can be expected that roughly 20% of small incidentalomas will grow on repeat imaging, with higher rates in patients with tumor syndromes such as neurofibromatosis. Early intervention via biopsy and ablation in selected cases can provide tissue diagnosis, alleviate family anxieties, and potentially prevent future morbidity in these patients with enlarging lesions.

Indexed as

AstrocytomaBrain NeoplasmsLaser TherapyNeoplasms, NeuroepithelialAdolescentBiopsyChildFemaleHumansIncidental FindingsMagnetic Resonance ImagingMalePediatric brain incidentaloma mass biopsy laser LITT

Identifiers

PMID41396212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.