Evidence map›Paper›PMID 41395932›Full record

ArticleJournal of virology2026

Identification and analysis of the crucial holin domain and sites and the bactericidal activity of a holin-endolysin lysis cassette from phage PZL-Ah152 against

Chao Feng, Yan Cheng, Shuang Liang, Ruiqi Liang, Jiahao Yu, Shun Wang, Hui Guo, Xiaofeng Shan, Dongxing Zhang, Aidong Qian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bacteriophages AgainstViruses · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chao Feng *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.ORCID 0009-0002-1893-412X
Yan Cheng *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Shuang LiangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Ruiqi LiangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Jiahao YuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Shun WangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Hui GuoCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xiaofeng ShanCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Dongxing ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Aidong QianCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Wuwen SunCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Lei ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.ORCID 0000-0002-1869-5096

Funding

Education Department of Jilin Province JJKH20250595KJJilin Provincial Postdoctoral Science FoundationJilin Provincial Scientific and Technological Development Program (Jilin Scientific and Technological Development Program) 20250601039RC
6 · The paper itself

Abstract

With the increasing prevalence of antibiotic-resistant bacteria, phage therapy has garnered significant attention. Holin and lysin play essential roles in the phage-induced lysis of bacteria. This study investigated the functions of the holin protein Hol 46 and the lysozyme protein Lys 17 from the phage PZL-Ah152 and the mechanisms underlying the action of the fusion protein Hol 46_Lys 17. Assays, including membrane protein extraction tests and fluorescence microscopy, verified that the Hol 46 protein localized to the cell membrane and significantly inhibited the growth of

Indexed as

Aeromonas hydrophilaBacteriophagesEndopeptidasesViral ProteinsAnimalsAnti-Bacterial AgentsBacteriolysisCell MembraneEscherichia coliFish DiseasesGram-Negative Bacterial InfectionsMuramidasePhage TherapyProtein DomainsAnti-Bacterial AgentsendolysinEndopeptidasesMuramidaseViral Proteinsfusion proteinholinlysinmechanism of actionphage

Identifiers

PMID41395932
PMCPMC12817945

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.