ReviewChemistry (Weinheim an der Bergstrasse, Germany)2026
Deprotective Functionalization: An Emerging Concept for Amine Reactivity.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Deprotective Alkylation: A Platform for Alcohol-to-Amine Interconversion Using Nonafluoromesitylenesulfonamides.Angewandte Chemie (International ed. in English) · 2026Article
- Deprotective Functionalization: An Emerging Concept for Amine Reactivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Protecting groups are widely employed in multi-step syntheses with the goal to downregulate the reactivity of certain functional groups. Their use, while often unavoidable, comes with notable drawbacks including increased costs and waste, as well as typically adding two (nonstrategic) synthetic steps to a given sequence. Moreover, late-stage deprotection of highly functionalized compounds can pose challenges. We introduced an approach termed deprotective functionalization, allowing for direct conversion of a protected functional group into a new one without requiring a separate deprotection event. Interestingly, in this paradigm the protecting group not only prevents side reactions, but also primes the protected functionality for selective transformations. This article provides a conceptual framework for this approach and discusses related strategies, currently limited to protected amines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.