Evidence map›Paper›PMID 41395716›Full record

ReviewMedicinal chemistry (Shariqah (United Arab Emirates))2025

A Review of the Medicinal Importance and Perspectives of the 2-isoxazoline Scaffold.

Shilpi Pathak, Pooja Singh, Gaurav Jadon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shilpi PathakDepartment of Pharmacy, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Pooja SinghDepartment of Pharmacy, Anjali College of Pharmacy, Etmadpur, Agra, Uttar Pradesh, 283202, India.
Gaurav JadonDepartment of Pharmacy, Mankind Pharma Limited, Navi Mumbai, 400706, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2-isoxazoline scaffold has emerged as a key structure in medicinal chemistry, with great therapeutic potential for a wide range of biological targets. This review investigates the medicinal value of the 2-isoxazoline scaffold, emphasizing its adaptability and usefulness in the development of new medications. Isoxazoline has a wide range of biological actions, including antibacterial, anti-inflammatory, anticancer, and anti-parasitic effects, which are due to their distinct structural features and capacity to interact with a variety of biological processes. The synthesis, functionalization, and pharmacological uses of isoxazoline derivatives are rigorously studied, yielding information about their modes of action and therapeutic value. This review emphasizes the promise of isoxazoline-based molecules in tackling current medical difficulties and lays the way for future research in this vibrant field of medicinal chemistry.

Indexed as

IsoxazolesAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsHumansMolecular StructureAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsIsoxazoles2-Isoxazolineheterocyclic structures.medicinal importancepharmacological activitysynthesistherapeutic potential

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.