ArticleRecent advances in drug delivery and formulation2025
Preparation and Characterization of Vitamin C Aquasomes.
Article in Recent advances in drug delivery and formulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAquasomes are water-based nanocarriers widely used in pharmaceutical applications for the delivery of various molecules.
aimThis research examines the preparation and characterization of vitamin C-loaded aquasomes.
methodsThe aquasomes were prepared by using colloidal precipitation and sonication methods. Various characterizations, including particle size, polydispersity index (PDI), and zeta potential, were performed on the core, lactose coating, and final formulation of vitamin C-loaded aquasomes. Further analysis was carried out using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). Additionally, the in vitro release profile of vitamin C from the aquasomes was compared with that of a commercially available vitamin C formulation and a shelf-life analysis was conducted.
resultsThe addition of lactose and vitamin C led to an increase in the particle size of the core, from 348 nm to 654 nm, while the zeta potential decreased from -31.9 mV to -12.8 mV. The percent payload was found to be 52.63%. TGA results indicated weight loss in HAP, suggesting thermal degradation, while DSC analysis revealed the melting points of lactose sugars and the thermal behavior of vitamin C. The dissolution results show that vitamin C-loaded aquasomes released 4- 6% more of the vitamin in acidic (pH 1.2) and phosphate buffer (pH 6.8) environments over 90 minutes, compared to commercial vitamin C products. The aquasomes exhibited excellent stability, maintaining over 90% of their potency over 90 days.
conclusionVitamin C-loaded aquasomes have been successfully prepared and demonstrated better performance compared to commercial products. This study suggests that aquasomes keep vitamin C stable and may improve its absorption in the body.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.