Evidence map›Paper›PMID 41395604›Full record

ArticleFrontiers in oncology2025

Impact of KRAS G12C mutation on the efficacy of chemoradiotherapy in patients with unresectable stage II or III non-small cell lung cancer.

Jean Cabon, Delphine Lerouge, Sebastien Thureau, Jacques Balosso, Marin Guigo, Radj Gervais, Catherine Dubos, Pascal Dô, Pierre Demontrond, Hubert Curcio and 11 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current Perspectives on Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jean CabonDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Delphine LerougeDepartment of Radiation Oncology, Centre François Baclesse, Caen, France.
Sebastien ThureauDepartment of Radiation Oncology, Centre Henri Becquerel, Rouen, France.
Jacques BalossoDepartment of Radiation Oncology, Centre François Baclesse, Caen, France.
Marin GuigoDepartment of Radiation Oncology, Centre François Baclesse, Caen, France.
Radj GervaisDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Catherine DubosDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Pascal DôDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Pierre DemontrondDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Hubert CurcioDepartment of Medical Oncology, Centre François Baclesse, Caen, France.
Simon DeshayesDepartment of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France.
Jeannick MadelaineDepartment of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France.
Dimitri Leite FerreiraDepartment of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France.
Leonard JacsonDepartment of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France.
Kilian LecrosnierUMR6252 CIMAP (Research Center for Ions, Materials, and Photonics), Team Applications in Radiobiology with Accelerated Ions, CEA-CNRS-ENSICAEN-Université de Caen Normandie, Caen, France.
François ChevalierUMR6252 CIMAP (Research Center for Ions, Materials, and Photonics), Team Applications in Radiobiology with Accelerated Ions, CEA-CNRS-ENSICAEN-Université de Caen Normandie, Caen, France.
Florian GuisierDepartment of Pneumology, Centre Hospitalier Universitaire de Rouen, Rouen, France.
Edouard DantoingDepartment of Pneumology, Centre Hospitalier Universitaire de Rouen, Rouen, France.
Alexandra LeconteDepartment of Clinical Research, Centre François Baclesse, Caen, France.
François ChristyDepartment of Clinical Research, Centre François Baclesse, Caen, France.
Mathieu CésaireDepartment of Radiation Oncology, Centre François Baclesse, Caen, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Approximately 35% of patients with non-small cell lung cancer (NSCLC) have locally advanced disease. Despite treatment with chemoradiotherapy (CRT) and consolidation immunotherapy, overall survival remains below 50% at 5 years. Kirsten rat sarcoma ( Methods: We conducted a multicenter retrospective study of unresectable stage II or III NSCLC treated with CRT in four French hospitals between January 2014 and December 2022. The primary endpoint was the objective response rate (ORR) for Results: Our study included 267 patients, and 73 patients had Conclusion:

Indexed as

chemoradiotherapyKRAS G12C mutationKRAS mutantlocally advance diseasenon-small cell lung cancer

Identifiers

PMID41395604
PMCPMC12695551

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.