Evidence map›Paper›PMID 41395561›Full record

ArticleInternational cancer conference journal2025

High-grade gliomas derived from an ovarian mature teratoma: clonal dynamics and genetic insights.

Kota Yamauchi, Junzo Hamanishi, Koichi Watanabe, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Hiroyuki Katsuragawa, Koji Yamanoi, Takashi Motohashi, Yuko Hosoe, Ken Yamaguchi and 9 more

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Article in International cancer conference journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kota Yamauchi *Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.
Junzo Hamanishi *Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.ORCID 0000-0002-7750-0623
Koichi Watanabe *Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.
Nobuyuki KakiuchiThe Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.
Yasuhide TakeuchiDepartment of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hiroyuki KatsuragawaDepartment of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Koji YamanoiDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.
Takashi MotohashiDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Yuko HosoeDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.
Ken YamaguchiDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.
Kiyoshi YamaguchiDivision of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Tsutomu TabataDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Yoichi FurukawaDivision of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yohei MineharuDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-6346-3999
Yoshiki ArakawaDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0003-4626-4645
Seishi OgawaThe Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.
Sachiko MinamiguchiDepartment of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Masaki MandaiDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-Ku, Kyoto, 606-8507 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-grade glioma (HGG) arising from a mature ovarian teratoma is extremely rare and its genetic alterations remain largely unknown. We report a case of WHO Grade 4 HGG (HGG-G4) developing 3 years after cystectomy for ovarian mature teratoma, where a WHO Grade 3 HGG (HGG-G3) was identified upon pathological reevaluation. Whole-exome sequencing confirmed the clonal relationship between HGG-G3 and HGG-G4, revealing genome-wide copy-neutral loss of heterozygosity, copy-number alterations, and whole-genome doubling in both HGGs. Genomic and epigenetic analyses have suggested multistep tumorigenesis and clonal alteration during the clinical course, particularly in response to chemotherapy, in HGGs arising from ovarian teratomas. Supplementary Information: The online version contains supplementary material available at 10.1007/s13691-025-00790-x.

Indexed as

High-grade gliomaMalignant transformationMulti-step tumorigenesisOvarian teratomaWhole-exome sequencing

Identifiers

PMID41395561
PMCPMC12696273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.