Evidence map›Paper›PMID 41395546›Full record

ArticleIntegrative organismal biology (Oxford, England)2025

Why not both? A case study in measuring cortisol and corticosterone.

S E Westrick, R T Paitz, E K Fischer

Abstract read
In one paragraph

Article in Integrative organismal biology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S E WestrickDepartment of Biology, Wake Forest University, Winston-Salem, NC 27103, USA.ORCID https://orcid.org/0000-0002-5381-1048
R T PaitzSchool of Biological Sciences, Illinois State University, Normal, IL 61790, USA.
E K FischerDepartment of Evolution, Ecology and Behavior, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID https://orcid.org/0000-0002-2916-0900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A general tenet in stress physiology is that the hypothalamic-pituitary-adrenal axis predominantly produces one glucocorticoid (GC) in response to stressors. However, most vertebrates produce both cortisol and corticosterone, these steroids show variation across species in absolute levels, relative proportions, and stress responsivity, and they regulate much more than just stress physiology. In the present commentary, we argue that focusing on a single GC may not capture the whole story, presenting an overview of previous studies and an example from our own work on poisons frogs-a group relatively new to endocrinological studies. We originally set out to validate non-invasive waterborne hormone measurements in our focal species, the dyeing poison frog

Identifiers

PMID41395546
PMCPMC12696386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.