ArticleFrontiers in microbiology2025
Microbial coinfection keratitis: clinical spectrum, pathogen distribution, and antimicrobial susceptibility in an 8-year retrospective study.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Temporal trends and shifting mycological spectrum of infectious keratitis in Egypt before, during and after the COVID-19 pandemic: a four-year laboratory-based surveillance study.BMC infectious diseases · 2026Article
- Current status on antimicrobial resistance in keratitis.Indian journal of ophthalmology · 2026Article
- Evaluation of Adhesion and Co-culture Efficacy Assays of Antifungals and Chlorhexidine Against Acanthamoeba and Candida Species Associated with Severe Infectious Keratitis.Current microbiology · 2026Article
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5 authors.
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Abstract
Background: Coinfection keratitis, involving concurrent infections by bacteria and fungi, poses diagnostic and therapeutic challenges. This study aimed to describe the microbiological and clinical characteristics of keratitis co-infections, including prevalence, predisposing factors, treatment and antimicrobial susceptibility profiles, in patients from a tertiary ophthalmology referral center in Mexico City. Methods: This retrospective and descriptive study analyzed data collected over an 8-year period (2012-2020) following STROBE guidelines. Corneal samples from patients diagnosed with infectious keratitis were cultured. Only cases with confirmed coinfections-defined as the isolation of more than one microorganism-were included. Microbiological identification and antimicrobial susceptibility were analyzed. Clinical data included demographics, risk factors, visual acuity, corneal reepithelialization, and surgical interventions. Results: A total of 306 microorganisms were isolated from 140 patients. Among them, 109 cases (78%) involved bacterial-bacterial coinfections, and 31 cases (22%) were bacterial-fungal coinfections. Conclusion: This retrospective and descriptive study characterizes microbial coinfections in infectious keratitis and provides contextual data from microbial cases from the same institution. Coinfection often involves multidrug-resistant organisms and occurs in patients with risk factors such as prior ocular surgery, contact lens use, or diabetes. Early identification and targeted therapy remain essential to improve clinical outcomes.
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