ArticleFrontiers in microbiology2025
Intratumoral microbiota omics analysis in head and neck squamous cell carcinoma.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Metabolic crosstalk between oral microbiota and the host in OSCC: emerging roles of microbial metabolites in tumor initiation and progression.Frontiers in cellular and infection microbiology · 2026Review
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5 authors.
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Abstract
Objective: The intratumoral microbiota plays a critical role in the progression of head and neck squamous cell carcinoma (HNSCC). This study aimed to comprehensively characterize the intratumoral microbiota in HNSCC and investigate its potential associations with tumor progression and host metabolic functions using a 4-nitroquinoline 1-oxide (4NQO)-induced murine model. Methods: A HNSCC mouse model was established through administration of 4NQO in drinking water. Histopathological and IHC analyses were performed to confirm tumor development and proliferative activity. The microbial composition of tumor and normal tissues was assessed using 5R 16S rDNA gene sequencing. Results: Successful induction of HNSCC was confirmed by histopathology and elevated PCNA expression. Significant decreases in microbial α-diversity and altered β-diversity were observed in tumor tissues. Enrichment of genera such as Conclusion: These findings demonstrate that intratumoral microbiota dysbiosis is closely associated with HNSCC progression. The study establishes a foundational murine model for further mechanistic research and suggests the potential of the intratumoral microbiota as a biomarker or therapeutic target in HNSCC.
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