Evidence map›Paper›PMID 41395373›Full record

ArticleSensors and actuators reports2026

RNA detection on a microfluidic platform using Thyclotides.

Harsha Amarasekara, Riley Lehman, Paniz Rezvan Sangsari, Nicole Y Morgan, Brian O'Farrell, Daniel H Appella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors and actuators reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harsha AmarasekaraSynthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry (LBC), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Riley LehmanSynthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry (LBC), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Paniz Rezvan SangsariBiomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Nicole Y MorganBiomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Brian O'FarrellDepartment of Research and Development, Altratech Ltd., Cork, Ireland.
Daniel H AppellaSynthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry (LBC), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Chemically Modified Peptide Nucleic AcidsZIADK031143 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2009 to 2025
$13.9M
Chemically Modified Peptide Nucleic AcidsZ01DK031143 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2005 to 2008
$892k
NOVEL AMINO ACIDS FOR CONFORMATIONAL AND STEREOCHEMICAL CONSTRAINTS IN PEPTIDESZ01DK031119 · NIDDK · DIABETES, DIGESTIVE, KIDNEY DISEASES · PI COHEN, L A · 1991 to 1992
–
Intramural NIH HHS Z01 DK031119Intramural NIH HHS Z01 DK031143Intramural NIH HHS ZIA DK031143
6 · The paper itself

Abstract

Nucleic acid detection is commonly used to diagnose pathogenic and genetic diseases. Diagnostics based on polymerase chain reaction (PCR) are routinely used to amplify and signal the presence of a target nucleic acid, but PCR-based methods are difficult to deploy at the patient's point-of-care and in resource-limited environments. This study reports a novel nucleic acid detection assay that utilizes chemically modified PNAs to directly detect a target RNA without enzymatic amplification. By incorporating

Indexed as

Assay DevelopmentBio-orthogonal PNAGold nanoparticles (AuNP)HIV-RNAMicrofluidicspeptide nucleic acid (PNA)thyclotide

Identifiers

PMID41395373
PMCPMC12700318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.