Evidence map›Paper›PMID 41395331›Full record

ArticleJCPP advances2025

The role of sleep deficiency in the relationship between adverse childhood experiences and early adolescent pain outcomes.

Thea Senger-Carpenter, Anao Zhang, Monica Ordway, Sarah A Stoddard, Terri Voepel-Lewis

Abstract read
In one paragraph

Article in JCPP advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thea Senger-CarpenterUniversity of Michigan School of Nursing Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0003-3082-5399
Anao ZhangUniversity of Michigan School of Social Work Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0002-3199-1113
Monica OrdwayYale School of Nursing Orange Connecticut USA.
Sarah A StoddardUniversity of Michigan School of Nursing Ann Arbor Michigan USA.
Terri Voepel-LewisUniversity of Michigan School of Nursing Ann Arbor Michigan USA.

Funding

Complexity: Innovations in Promoting Health through Team ScienceT32NR016914 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARJORIE E MCCULLAGH · 2017 to 2026
$3.5M
The Symptom-Associated Pathway to Substance Use and Misuse during AdolescenceR01DA052310 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VOEPEL-LEWIS, TERRI DIANE · 2021 to 2025
$1.9M
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during AdolescenceF31NR020837 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SENGER-CARPENTER, THEA · 2023 to 2023
$40k
NIDA NIH HHS R01 DA052310NINR NIH HHS F31 NR020837NINR NIH HHS T32 NR016914
6 · The paper itself

Abstract

Background: Sleep deficiency is common among youth exposed to adverse childhood experiences (ACEs) and may contribute towards persistent/recurrent pain (PRP). This study tested the hypotheses that sleep deficiency mediates the effect of ACEs on PRP and moderates the effect of ACEs on PRP exerted through anxiety and depression symptoms. Methods: We used 4 years of Adolescent Brain Cognitive Development Study® data to test our hypotheses. Annual assessments of sleep duration and quality (from the Sleep Disturbances Scale for Children), pain, anxiety, and depression (from the Child Behavior Checklist) were used to derive our measures. Structural equation modeling and sleep subgroup comparisons estimated effects of early childhood ACEs (measured with parent/youth surveys) on PRP (defined as pain reported for 3 or 4 years) via sleep duration and quality, accounting for effects of anxiety/depression symptoms. Results are presented as standardized adjusted odds ratios with 95% confidence intervals (adj. OR [95% CI]). Results: Data from 7912 youth were included, nearly one third of whom ( Conclusion: Sleep deficiency may underlie the effect of early ACEs on PRP, though anxiety and depression are likely important to these pathways regardless of sleep. Further investigation into the potentially mechanistic role of sleep deficiency in ACEs/pain associations is warranted.

Indexed as

adolescenceadverse childhood experiencespainsleep

Identifiers

PMID41395331
PMCPMC12698282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.