ArticleAmerican journal of cancer research2025
Patterns and risk factors of intracranial recurrence after surgical resection of brain metastases from malignant tumors.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe incidence of brain metastases is increasing, and surgical resection remains a key treatment modality. However, postoperative intracranial recurrence - including local recurrence (LR), distant brain recurrence (DBR), and leptomeningeal disease (LMD) - significantly impacts patient prognosis. Previous studies have predominantly focused on single tumor types and lacked systematic analyses of recurrence patterns and risk factors.
objectivesThis study aimed to investigate the incidence, temporal distribution, and independent risk factors associated with distinct postoperative recurrence patterns.
methodsDemographic, imaging, surgical, pathological, and post-treatment data from 198 patients who underwent resection of brain metastases were retrospectively analyzed. Kaplan-Meier and Fine-Gray models were used to evaluate recurrence timing, and a multinomial logistic regression model (using the non-recurrence group as reference) was applied to identify risk factors. A cause-specific Cox proportional hazards model was further employed to analyze recurrence timing while considering death as a competing risk.
resultsIntracranial recurrence occurred in 119 patients (60.1%). LR was the most frequent type (47.1%), whereas LMD developed latest (median 14.6
conclusionPostoperative intracranial recurrence after surgical resection of brain metastasis demonstrates distinct incidence rates, temporal profiles, and independent risk factors. These recurrence patterns and associated risks are highly dependent on the tumor type.
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