ArticleAmerican journal of cancer research2025
Adoption of multi-slice spiral computed tomography and multiparametric magnetic resonance imaging in the differential diagnosis of pancreatic cancer and chronic pancreatitis.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to assess the diagnostic value of combining computed tomography (CT) and magnetic resonance imaging (MRI) for differentiating pancreatic cancer (PCa) from chronic pancreatitis (CP). A total of 340 patients with pancreatic diseases were retrospectively included, comprising 173 cases of PCa and 167 cases of CP. The patients were randomly divided into a training set of 238 cases and a validation set of 102 cases, with the validation set comprising 52 cases of PCa (Group A) and 50 cases of CP (Group B). All patients underwent multi-slice spiral CT (MSCT) and multi-parametric MRI examinations. Imaging features and CT attenuation values were analyzed. Diagnostic sensitivity (Sen), specificity (Spe), and accuracy (Acc), and the area under the receiver operating characteristic curve (AUC) were compared among CT, MRI, and their combined application. The inter-group comparison indicated that pancreatic volume enlargement, invasion of surrounding tissues and major blood vessels, peripheral lymph node enlargement, inconspicuous arterial phase (AP) enhancement, and smooth dilation of the pancreatic duct (PD) and bile duct (BD) in Group A were markedly higher than those in Group B. Conversely, lesion calcification, fibrosis and pseudocyst formation, and irregular dilation of the PD and BD were less common in Group A than in Group B (
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