ArticleAmerican journal of cancer research2025
USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer, a lethal malignancy with a 5-year survival rate below 9%, is characterized by an immunosuppressive tumor microenvironment that facilitates immune evasion. Despite the clinical urgency, the molecular mechanisms driving the scarcity of cytotoxic T lymphocyte (CTL) infiltration, a hallmark of its immunologically 'cold' phenotype, remain poorly defined, which represents a critical barrier to developing effective immunotherapies. In this study, we identify ubiquitin-specific peptidase 18 (USP18) as a critical regulator of major histocompatibility complex I (MHC-I) degradation that enables immune evasion in pancreatic ductal adenocarcinoma (PDAC). In clinical PDAC samples, USP18 protein levels were significantly elevated and inversely correlated with MHC-I expression, independent of transcriptional regulation. Functionally, USP18 knockdown enhanced MHC-I surface expression, promoted CD8
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.