Evidence map›Paper›PMID 41395242›Full record

ArticleTransboundary and emerging diseases2025

Identification and Phylodynamic Analysis of the Siberian Subtype of Tick-Borne Encephalitis Virus in Tick-Bitten Patients From Northeastern China.

Zhiwei Wei, Ziyan Liu, Yu Liu, Ning Liu, Yuanning Ren, Shuzhen Han, Xiangyu Zheng, Xiaolong Lv, Zedong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiwei WeiDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0009-0004-8076-2386
Ziyan LiuDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0000-0003-3992-9194
Yu LiuDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0009-0003-7020-7832
Ning LiuDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0009-0006-4286-9232
Yuanning RenDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.
Shuzhen HanDepartment of Neurology, The Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia Forestry General Hospital, Yakeshi, Inner Mongolia Autonomous Region, China, imun.edu.cn.
Xiangyu ZhengDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0000-0001-9898-1748
Xiaolong LvDepartment of Neurology, The Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia Forestry General Hospital, Yakeshi, Inner Mongolia Autonomous Region, China, imun.edu.cn.ORCID https://orcid.org/0000-0001-8098-0130
Zedong WangDepartment of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, State Key Laboratory of Zoonotic Diseases, The First Hospital of Jilin University, Changchun, Jilin Province, China, jlu.edu.cn.ORCID https://orcid.org/0000-0001-8895-6944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Far Eastern (FE) tick-borne encephalitis virus (TBEV) was thought to be the only endemic subtype in northeastern China. However, in 2024, the Siberian (Sib) subtype of TBEV was found in ticks. This study investigates Sib-TBEV infection in tick-bitten patients in the region. A total of 2573 tick-bitten patients, including 506 inpatients and 2067 outpatients, were enrolled between April and September in both 2023 and 2024 and were tested for Sib-TBEV using real-time quantitative polymerase chain reaction (RT-qPCR). Seven cases were confirmed, with four among inpatients and three among outpatients. All four inpatients exhibited headaches and had hospital stays ranging from 5 to 21 days. Two inpatients with longer hospital stays showed additional symptoms: one experienced dizziness and fatigue, while the other exhibited liver injury and neurological symptoms, including facial paralysis, dysarthria, and meningeal signs. All patients recovered and were discharged without sequelae. Seven Sib-TBEV complete genomes were amplified and classified into the Sib-TBEV Zausaev and Vasilchenko lineages. Bayesian analysis estimated that the most recent common ancestor (tMRCA) of these strains dates to a period between 1898 and 1983, with possible migration pathways from Irkutsk or Zabaykalsky to the Daxing'an Mountains (DXAM) in northeastern China. We identified Sib-TBEV-infected patients in northeastern China and characterized their epidemiological and clinical features. Sib-TBEV may have been circulating in northeastern China for decades, underscoring the need for TBEV surveillance in ticks, animals, and tick-bitten patients.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneTick BitesAdultAgedAnimalsChinaFemaleHumansMaleMiddle AgedPhylogenyNortheastern ChinaSiberian subtypetick-bitten patientstick-borne encephalitis virus (TBEV)ticks

Identifiers

PMID41395242
PMCPMC12698504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.