ReviewTherapeutics and clinical risk management2025
Perioperative Blood Pressure Optimization to Improve Outcomes in Orthopedic Patients: A Clinical Review.
Review in Therapeutics and clinical risk management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
Perioperative blood pressure fluctuations significantly contribute to postoperative complications in orthopedic surgery, particularly among high-risk patients. This clinical review synthesizes current evidence on individualized blood pressure management across the perioperative continuum, highlighting procedure-specific risks such as bone cement implantation syndrome, tourniquet-induced hemodynamic changes, and cerebral hypoperfusion in the beach-chair position. Special considerations for vulnerable populations, including frail elderly and anticoagulated patients, are discussed to balance bleeding and thrombotic risks. Maintaining mean arterial pressure within 10-20% of baseline through tailored anesthesia, goal-directed fluid therapy, and continuous monitoring is associated with improved outcomes. A multidisciplinary, risk-stratified approach is recommended to reduce perioperative morbidity and improve postoperative outcomes. Future research should validate personalized blood pressure targets and explore the role of advanced hemodynamic monitoring in enhancing patient safety.
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