ArticleRSC advances2025
A dual-responsive NIR fluorescent probe for GSH and viscosity: applications in models of cellular inflammation and apoptosis.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Near-infrared Fluorescent Probe for Sensitive Detection of Viscosity in Biosystems and Beverages Spoilage.Journal of fluorescence · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer remains a leading cause of global death. Because high levels of glutathione (GSH) and increased intracellular viscosity are known as key biomarkers linked to cancer cells, we developed a dual-responsive near-infrared (NIR) fluorescent probe, NIR-NOS, for simultaneous detection of mitochondrial GSH and viscosity. NIR-NOS uses NOS-Br as the GSH-responsive component and a C[double bond, length as m-dash]C bond within the NIR-1 part as the viscosity-sensitive element, with its fluorescence enhanced through the restriction of intramolecular rotation. When exposed to GSH, breaking the ether bond causes a significant fluorescence turn-on. At the same time, increased viscosity limits the rotation of the C[double bond, length as m-dash]C bond, boosting the fluorescence at 640 nm by about 50 times. Spectroscopic tests showed excellent selectivity for GSH over other substances, with a detection limit of 0.44 µM. Importantly, NIR-NOS shows low toxicity and effectively targets mitochondria. This probe allows for visualization of both natural and induced changes in mitochondrial GSH, as well as real-time observation of intracellular viscosity shifts, demonstrated in studies using nystatin (Nys) and lipopolysaccharide (LPS) to alter these factors. Additionally, because of its mitochondrial targeting and dual-response function, NIR-NOS enables real-time tracking of key mitochondrial activities, such as vesicle formation and programmed cell death triggered by Nys. This offers deeper understanding of mitochondrial redox regulation and environmental changes. Overall, this study introduces NIR-NOS, a thoughtfully designed, multifunctional NIR fluorescent probe with great potential for advanced cancer imaging and live,
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.