Evidence map›Paper›PMID 41395114›Full record

ArticleInternational journal of genomics2025

CLEC4G Reverses Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing PD-1 Expression via the Wnt/

Kemin Xiao, Jin Yan, Guangxi He, Bin He, Qi Wang

Abstract read
In one paragraph

Article in International journal of genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kemin XiaoDepartment of General Surgery, Daye People's Hospital, Daye, Hubei, China.
Jin YanDepartment of General Surgery, Daye People's Hospital, Daye, Hubei, China.
Guangxi HeDepartment of General Surgery, Daye People's Hospital, Daye, Hubei, China.ORCID https://orcid.org/0009-0002-3866-2432
Bin HeDepartment of General Surgery, Daye People's Hospital, Daye, Hubei, China.
Qi WangDepartment of General Surgery, Daye People's Hospital, Daye, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective was to analyze the effect of Methods: Differentially expressed genes (DEGs) were screened from the GSE101685 dataset, followed by functional enrichment analysis. Subsequently, Results: A total of 51 DEGs were identified in the GSE101685 dataset. After silencing CLEC4G expression, the activities of both PLC/PRF/5 and PLC/PRF/5-R, as well as the expression of PD-1, were decreased, while apoptosis was increased ( Conclusion:

Indexed as

bioinformatics analysisCLEC4Gdrug resistancehepatocellular carcinomaimmune escapelenvatinib

Identifiers

PMID41395114
PMCPMC12697085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.