Evidence map›Paper›PMID 41394958›Full record

ArticleMedComm2025

Association Between Prophylactic Anti-Seizure Medication and Early Post-Traumatic Seizures: An International Observational Multicenter Study.

Jian Ji, Juan D Roa G, Shu-Ling Chong, Quan Wang, Chin Seng Gan, Jane P W Ng, Thelma Elvira Teran Miranda, Freddy Israel Pantoja Chamorro, Lawrence Chi Ngong Chan, Qalab Abbas and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Jian JiPediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.
Juan D Roa GPediatric Collaborative Latin American Network (LARed Network) Pediatric Intensive Care Unit Los Cobos Medical Center Universidad Del Bosque Bogotá Colombia.
Shu-Ling ChongDepartment of Emergency Medicine KK Women's and Children's Hospital Singapore SingHealth Duke-NUS Global Health Institute, Duke-NUS Medical School Singapore Singapore.
Quan WangPediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.
Chin Seng GanDepartment of Pediatrics University Malaya Medical Centre Kuala Lumpur Malaysia.
Jane P W NgKK Research Centre KK Women's and Children's Hospital Singapore Singapore.
Thelma Elvira Teran MirandaDepartment of Pediatrics Hospital Del Niño Manuel Ascencio Villarroel Cochabamba Bolivia.
Freddy Israel Pantoja ChamorroIntensive Care Unit Hospital Infantil Los Angeles Pasto Colombia.
Lawrence Chi Ngong ChanDepartment of Pediatrics Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong SAR China.
Qalab AbbasDepartment of Pediatrics and Child Health Aga Khan University Hospital Karachi Pakistan.
Jacqueline S M OngDepartment of Pediatrics Yong Loo Lin School of Medicine Khoo Teck Puat National University Children's Medical Institute National University Hospital Singapore National University of Singapore Singapore Singapore.
Ivan J ArdilaPediatric Critical Care Clinica UROS Neiva Colombia.
Yasser M KazzazDepartment of Pediatrics King Abdullah International Medical Research Center Riyadh Saudi Arabia.
Jesús A Domínguez-RojasDepartment of Pediatrics and Pediatric Critical Care Medicine Hospital Nacional Hipolito Unanue El Agustino Peru Pediatric Chapter of the Peruvian Society of Intensive Care Medicine Lima Peru.
Hiroshi KurosawaDepartment of Pediatric Critical Care Medicine Hyogo Prefectural Kobe Children's Hospital Kobe Japan.
Susana Beatriz Reyes DomínguezPediatric Intensive Care Unit Pediatric Department Virgen De La Arrixaca Hospital Murcia Spain.
Natalia Elizabeth Gómez ArriolaEmergency Department Hospital Del Trauma Asunción Paraguay.
Natalia Zita WatzlawikDepartment of Pediatric Intensive Care Unit Hospital De Pediatric Garrahan Ciudad Autónoma de Buenos Aires Buenos Aires Argentina.
Adriana Yock-CorralesEmergency Department National Children's Hospital "Dr. Carlos Saenz Herrera," CCSS San José Costa Rica.
Rubén Eduardo Lasso PalominoPediatric Intensive Care Unit Fundación Valle del Lili Cali Valle del Cauca Colombia.
Gabriela AparicioPediatric Critical Care Unit Hospital De Ninos de La Plata Sor María Ludovica Buenos Aires Argentina.
Paula CaporalPediatric Intensive Care Unit Children's Hospital "Sor Maria Ludovica Buenos Aires Argentina Pediatric Collaborative Latin American Network (LARed Network) Buenos Aires Argentina.
Rosa Elena de la Torre GómezHospital Civil de Guadalajara Guadalajara Mexico.
Chunfeng LiuPediatric Department Shengjing Hospital China Medical University Shenyang Liaoning China.
Rujipat SamransamruajkitDepartment of Pediatrics Pediatric Critical Care Division King Chulalongkorn Memorial Hospital Chulalongkorn University Bangkok Thailand.
Nattachai AnantasitPediatric Critical Care Division Department of Pediatrics Ramathibodi Hospital Bangkok Thailand.
Deborah M TurinaPediatric Intensive Care Unit Ricardo Guiterrez Children's Hospital Buenos Aires Argentina.
Marisol Fonseca FloresPediatric Critical Care Mexican Institute of Social Security México City Mexico.
Pei-Chuen LeePediatrics Department UKM Specialist Children's Hospital, Kuala Lumpur Wilayah Persekutuan Malaysia.ORCID https://orcid.org/0000-0002-0200-9354
Francisco J Pilar-OriveDepartment PICU Hospital Universitario de Cruces Barakaldo Spain.
Hongxing DangDepartment of Pediatric Intensive Care Unit Children's Hospital of Chongqing Medical University Chongqing China.
Yek Kee ChorDepartment of Pediatrics Sarawak General Hospital Sarawak Malaysia.
Meixiu MingDepartment of Pediatric Intensive Care Unit Children's Hospital of Fudan University Shanghai China.
Juan C Jaramillo-BustamantePediatric Intensive Care Unit General Hospital of Medellín "Luz Castro De Gutiérrez Medellín Colombia.
Sebastián González-DambrauskasPediatric Collaborative Latin American Network (LARed Network) Department of Pediatrics and Pediatric Intensive Care Unit School of Medicine Hospital Pereira Rossell University of the Republic Montevideo Uruguay.
Jan Hau LeeChildren's Intensive Care Unit KK Women's and Children's Hospital Singapore Singapore.
Suyun QianPediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence for the use of prophylactic anti-seizure medication (ASM) in traumatic brain injury (TBI) in reducing the occurrence of early post-traumatic seizure (EPTS) remains equivocal. This study aimed to analyze the prevalence of EPTS in children with TBI, compare clinical characteristics of those with and without EPTS, and explore the association between prophylactic ASM and EPTS. We performed an observational study among 28 pediatric intensive care units in 15 countries from January 2014 to October 2022. The rate of EPTS was compared between individuals prescribed prophylactic ASM and those who were not. Logistic regression was used to examine the association between ASM and EPTS. Among 697 children with TBI, 161 (23.1%) developed EPTS and 280 (40.2%) received prophylactic ASM treatment. Use of prophylactic ASM was associated with a lower likelihood of developing EPTS (27/280 (9.6%) vs. 134/417 (32.1%),

Identifiers

PMID41394958
PMCPMC12696337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.