ArticleFrontiers in physiology2025
2-Kidney-1-clip hypertension is not attenuated in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) channel.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Do stretch sensors expressed by aortic baroreceptors interact with circulating estradiol to mediate baroreflex sensitivity in hypertension?Frontiers in neuroscience · 2026Review
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Abstract
Introduction: Chemical ablation of renal sensory nerves using agonists for transient receptor potential vanilloid-1 (TRPV1) lowers arterial blood pressure (ABP) in multiple experimental models of hypertension. Interestingly, both afferent renal nerve activity and arterial blood pressure were significantly attenuated in male Trpv1 Methods: 2K1C surgery was performed by placement of a 0.5mm length of polyetrafluoroethylene tubing around the right renal artery. Experiment 1 quantified the proportion of TRPV1 mouse renal sensory neurons in both sham and 2K1C after a kidney injection of the tracer wheat germ agglutinin conjugated to AlexaFluor 647. Experiment 2 assessed ABP using telemetry in WT and Trpv1 Results: First, the majority of retrogradely labeled neurons were located in the ipsilateral T10-L2 dorsal root ganglion and small to medium sized (10-29um diameter). Approximately 60% were TRPV1-positive. Second, 2K1C significantly increased ABP in both male and female WT and Trpv1 Conclusion: These findings suggest that a subset of renal sensory neurons in the mouse are TRPV1-positive, and renovascular 2K1C hypertension is not attenuated in the Trpv1
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