Evidence map›Paper›PMID 41394879›Full record

ArticleFrontiers in immunology2025

IFN-γ induced the formation of foamy macrophages via CD40 signal to control

Shaoyan Zhang, Ya Feng, Xianwei Wu, Jiajun Chen, Huiyong Zhang, Li Tian, Hai Lou, Liping Wang, Ben Su, Xing Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shaoyan Zhang *Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ya Feng *Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xianwei Wu *Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jiajun Chen *Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Huiyong ZhangInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li TianInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hai LouDepartment of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Liping WangInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ben SuInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xing HuangInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lei QiuInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dingzhong WuInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei ShaDepartment of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Zhenhui LuInstitute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Foamy macrophages (FMs) have recently shown potential in restricting the intracellular growth of Methods: Clinical blood samples, murine infected models (WT and IFN-γ Results: During the acute infection phase, the lipid droplets (LDs) in peripheral blood mononuclear cells significantly increased, along with the upregulation of serum IFN-γ levels. Experiments with IFN-γ Conclusion: This study established the IFN-γ-CD40-DGAT1 axis as an important role in the formation of FMs and the control of

Indexed as

CD40 AntigensFoam CellsInterferon-gammaMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsDisease Models, AnimalHumansLipid DropletsMiceMice, Inbred C57BLMice, KnockoutSignal TransductionCD40 AntigensInterferon-gammaCD40foamy macrophagesIFN-γlipid dropletsMycobacterium abscessus

Identifiers

PMID41394879
PMCPMC12695758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.