Evidence map›Paper›PMID 41394853›Full record

ReviewFrontiers in immunology2025

Overview of immune checkpoint inhibitor associated myocarditis mechanisms diagnostics and treatment.

Shuhui Feng, Bingru Zhao, Shuo Sha, Xingpeng Bu, Zhenzhen Zhang, Guoying Liu, Huanzhen Chen

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome: a single-center case series and systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Hyperbaric Oxygen Therapy in Experimental Autoimmune Myocarditis: Insights from Preclinical Models to Translational Perspectives.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuhui FengDepartment of Cardiology, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.
Bingru ZhaoDepartment of Cardiology, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.
Shuo ShaDepartment of Cardiology, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.
Xingpeng BuDepartment of Geriatrics, Bethune Hospital, School of Medicine, Shanxi Medical University, Taiyuan, China.
Zhenzhen ZhangDepartment of Cardiology, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.
Guoying LiuDepartment of Emergency, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.
Huanzhen ChenDepartment of Cardiology, First Hospital of Shanxi Medical University, School of Medicine, Shanxi Medical University, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitor-associated myocarditis (ICI-M) has emerged as a rare yet fulminant immune-related adverse event, characterized by high mortality and diagnostic complexity. Recent studies implicate loss of immune tolerance through PD-1/PD-L1 or CTLA-4 blockade, expansion of autoreactive CD8

Indexed as

Immune Checkpoint InhibitorsMyocarditisAnimalsHumansNeoplasmsImmune Checkpoint Inhibitorscardiovascular magnetic resonanceelectrocardiographyimmune checkpoint inhibitorsimmune responsesmyocarditistherapy

Identifiers

PMID41394853
PMCPMC12698404

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.