Evidence map›Paper›PMID 41394852›Full record

ArticleFrontiers in immunology2025

Single-cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and

Zihui Zhao, Suyue Huang, Wei Huang, Wei Song, Li Liu, Jun Chen, Renfang Zhang, Yinzhong Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zihui Zhao *Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Suyue Huang *Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wei HuangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wei SongShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Renfang ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenShanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human immunodeficiency virus (HIV) and Methods: To capture early untreated states, we applied single-cell RNA sequencing (scRNA-seq) to peripheral blood mononuclear cells from healthy controls, and from participants newly diagnosed with HIV mono-infection or HIV-Mtb co-infection, before therapy initiation. Integration guided by a Directed Acyclic Graph (DAG) inferred a pseudo-temporal trajectory from health to HIV infection to co-infection. Results: Along this continuum, TNF-α and TGF-β signaling progressively declined in CD8 Discussion: Our study provides a single-cell roadmap of HIV-Mtb co-infection and identifies Th1/Th17 imbalance and MHC-I-biased T-cell signaling reconfiguration as candidate targets for restoring immune homeostasis.

Indexed as

Cellular ReprogrammingCoinfectionHIV InfectionsHost-Pathogen InteractionsMycobacterium tuberculosisTranscriptomeTuberculosisAdultFemaleGene Expression ProfilingHumansMaleMiddle AgedSignal TransductionSingle-Cell AnalysisHIV-Mtb co-infectionsingle-cell transcriptomicsT cell exhaustionTh1/Th17 imbalanceTNF signaling

Identifiers

PMID41394852
PMCPMC12698600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.