Evidence map›Paper›PMID 41394833›Full record

ArticleFrontiers in immunology2025

NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.

Stephanie DeStefano, Ruth Grychtol, Dominik Funken, Anika Habener, Stephanie Tamm, Frauke Stanke, Wolfgang Greiner, Kirsten Beyer, Eckard Hamelmann, Michael Kabesch and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stephanie DeStefanoDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Ruth GrychtolDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Dominik FunkenDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Anika HabenerDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Stephanie TammDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Frauke StankeDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Wolfgang GreinerDepartment for Health Economics and Health Care Management, School of Public Health, Bielefeld University, Bielefeld, Germany.
Kirsten BeyerDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Eckard HamelmannChildren's Center Bethel, Evangelisches Klinikum Bethel, University Bielefeld, Bielefeld, Germany.
Michael KabeschUniversity Children's Hospital Regensburg (KUNO), St. Hedwig's Hospital of the Order of St. John and the University of Regensburg, Regensburg, Germany.
Erika von MutiusInstitute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.
Bianca SchaubDepartment of Pulmonary and Allergy, Dr. von Hauner Children's Hospital, University Children´s Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Adan Chari JirmoDepartment of Pediatric Surgery, Hannover Medical School, Hannover, Germany.
Gesine HansenDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
CHAMP study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The inflammasome NLRP3 (NOD-like receptor family pyrin domain containing 3) is critical for epithelial barrier integrity. Allergic asthma is characterized by airway inflammation, airway hyperresponsiveness (AHR), and mucus hypersecretion. To date, the key players and underlying mechanisms in the interaction between NLRP3 and epithelial barrier integrity in type 2-mediated allergic asthma are poorly understood. Objective: Our study aims to evaluate the protective mechanisms of NLRP3 on airway epithelium and its structural and functional components during type 2-mediated allergic asthma inflammation. Methods: Using an experimental model of allergic airway disease, NLRP3-deficient (NLRP3 Results: In comparison to WT mice, NLRP3 Conclusion: NLRP3 is essential for epithelial barrier integrity in the lung and protects from the development of allergic asthma in a murine model.

Indexed as

AsthmaNLR Family, Pyrin Domain-Containing 3 ProteinRespiratory HypersensitivityRespiratory MucosaAnimalsDisease Models, AnimalEpithelial CellsHumansInflammasomesMiceMice, Inbred C57BLMice, KnockoutOvalbuminInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOvalbuminasthmaepithelial barrierNLRP3Th2-inflammationtight junction proteins

Identifiers

PMID41394833
PMCPMC12695735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.