ReviewFrontiers in immunology2025
What's cooking? The effect of temperature on the immune response.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Setup of a Simple and Cost-Effective pH-Sensitive Assay to Evaluate Phagocytosis in Rainbow Trout (Animals : an open access journal from MDPI · 2026Article
- Strategies and limitations of the bat immune response toFrontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals have evolved to live in different environs, with some having developed specialised features to support survival in adverse conditions, whilst others adapt behaviourally. Temperature impacts the immune system differentially, with lower temperatures impacting the adaptive immune response, but not the innate response. A reduction in adaptive immune capacity at lower temperatures can be due to a failure to effectively assemble MHC and may be a result of modifications of the plasma membrane structure or its viscosities. Higher temperatures can be beneficial initially, but can be disruptive if excessive. Ensuring the effectiveness of the adaptive immune response through optimal temperature regulation or manipulation, where possible, may support immunological fitness, ultimately enhance the conservation and biodiversity of wildlife species, and improve welfare outcomes for production animals and ourselves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.