Evidence map›Paper›PMID 41394802›Full record

ArticleFrontiers in immunology2025

Predictive value of peripheral blood CD4

Zheng Pan, Shihang Song, Yuan An, Lianyue Guan, Hongyu Liu, Wei Li

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zheng PanDepartment of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Shihang SongDepartment of Thoracic and Cardiovascular Surgery, Ezhou Central Hospital, Ezhou, China.
Yuan AnDepartment of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Lianyue GuanDepartment of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Hongyu LiuDepartment of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Wei LiDepartment of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early assessment of the efficacy of immune checkpoint inhibitor (ICI) therapy in advanced hepatocellular carcinoma (HCC) patients plays a crucial role. In this study, we systematically analyzed the predictive values of various lymphocyte subpopulations (CD4 Materials and methods: We systematically reviewed the clinical data of these patients in our hospital. Logistic regression analyses were conducted to identify variables predicting OR. Cut-off values were determined by maximizing Youden index. Then, patients were stratified based on these cut-off values, and Kaplan-Meier analysis with log-rank test was used to compare progression-free survival (PFS) and overall survival (OS) between groups. Results: A total of 41 patients were included. Multivariate logistic regression analysis revealed that W3 CD4 Conclusions: W3 CD4

Indexed as

Carcinoma, HepatocellularCD4-Positive T-LymphocytesImmune Checkpoint InhibitorsImmunotherapyKiller Cells, NaturalLiver NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesTreatment OutcomeImmune Checkpoint InhibitorsCD4+ T cellshepatocellular carcinoma (HCC)immunotherapyNK cellsoverall survival (OS)progression-free survival (PFS)treatment efficacy

Identifiers

PMID41394802
PMCPMC12698629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.