Evidence map›Paper›PMID 41394796›Full record

ArticleWellcome open research2025

Increased

Emily Williams, Maryline Fresquet, Gema Bolas, Shota Kaseda, Kevin A Goncalves, Andrew Steinsapir, Antony Adamson, David R Sherwood, Rachel Lennon

Abstract read
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. IncreasedWellcome open research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily Williams *Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, England, M13 9PT, UK.
Maryline Fresquet *Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, England, M13 9PT, UK.ORCID https://orcid.org/0000-0001-9530-6392
Gema Bolas *Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, England, M13 9PT, UK.
Shota KasedaManchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, England, M13 9PT, UK.
Kevin A GoncalvesDeerfield Discovery and Development, Deerfield Management Company, New York, NY, USA.
Andrew SteinsapirDeerfield Discovery and Development, Deerfield Management Company, New York, NY, USA.
Antony AdamsonGenome Editing Unit Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, England, M13 9PT, UK.ORCID https://orcid.org/0000-0002-5408-0013
David R SherwoodDepartment of Biology, Box 90338, Duke University, Durham, North Carolina, NC 27708, USA.
Rachel LennonManchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, England, M13 9PT, UK.ORCID https://orcid.org/0000-0001-6400-0227

Funding

Understanding how cells invade through basement membrane in vivoR35GM118049 · NIGMS · DUKE UNIVERSITY · PI David R Sherwood · 2016 to 2026
$6.8M
NIGMS NIH HHS R35 GM118049Wellcome Trust
6 · The paper itself

Abstract

Background: Alport syndrome is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and eye abnormalities. It is caused by variants in the Methods: In this study, we evaluated the transduction efficacy of Adeno-Associated Virus-9 with a green fluorescent protein cargo (AAV9-GFP) as a gene delivery vehicle in healthy and Alport ( Results: First we compared transduction levels of AAV9-GFP between healthy and Alport podocytes Conclusion: These findings underscore the potential of AAV9 for effective gene delivery in the context of Alport syndrome and show that the stage of disease at the time of injection plays a role in determining the efficiency of AAV transduction. Overall, this study provides a foundation for future therapeutic strategies aimed at correcting the underlying genetic defects.

Indexed as

AAVAlport syndromecollagen IVgene therapyglomeruluspodocyte

Identifiers

PMID41394796
PMCPMC12699215

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.